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David Letterman took a swipe at OWN Network talk show host Rosie O’Donnell during his Tuesday night monologue and it didn’t sit well with the newly-engaged comedian.

The on-air slight was about her bride-to-be Michelle Rounds. Letterman quipped, “The woman she is marrying, her fiancee, was driving…and her car broke down. And guess what happened? Rosie pulls up right behind her in her tow truck.”

Rosie responded Friday night on her show, “Why Dave? I don’t remember making fun of you when you had sex with all your interns! I didn’t do that. I didn’t make fun of your rampant, throbbing heterosexuality, did I Dave?”

She wasn’t done yet. “Dave, when you had that heart surgery, you shouldn’t have told the doctors to take out that whole thing. I remember when you had one, Dave, you were nice then.”

Not only do you appear to be anti-gay, you’re anti-tow truck driver and that just pisses me off.”

And so it goes… Check out the video below:


Photos: WENN